By G. David Perkin
An authoritative advent to Parkinson's affliction and its comparable problems and syndromes, this publication presents a concise evaluate of the sickness and its analysis and administration. the writer offers samples of medical, investigative (CT, MRI, and puppy) and pathological photos with succinct descriptive textual content of the problems featured. He describes the stipulations relating to Parkinson's ailment, and the photographs offer pathological macroscopic and microscopic sections, quite a few imaging stories, and info of circulate problems in most cases. The publication will function an invaluable educating instrument that demonstrates the imaging and pathology of the sickness.
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Additional resources for An Illustrated Pocketbook of Parkinson’s Disease and Related Disorders
Imaging is of value in demonstrating the particular changes occurring in the brain. CT can demonstrate ventricular dilatation and cortical atrophy, as well as hypodensities in the basal ganglia. MRI is more sensitive in detecting both lesions within the basal ganglia and in the thalamus. A chronic non-familial form of hepatic cerebral degeneration has been described. The clinical features are similar to those of Wilson’s disease, but there are no Kayser-Fleischer rings, and no evidence of abnormal copper accumulation.
SPECT can demonstrate reduced striatal blood flow compared with controls. Postmortem studies have established a reduction of both D1 and D2 receptors in the putamen. The radio active tracer [11C] raclopride is a selective reversible D2 receptor antagonist. Using these tracers, Huntington’s disease patients can be shown to have significant reductions in striatal D1 and D2 AN ILLUSTRATED POCKETBOOK OF PARKINSON’S DISEASE 51 Figure 53 Postischemic dystonic posturing of the hand receptor density. The abnormalities apply both to the choreic and akinetic-rigid forms of the disease, but are greater in the latter group (Figure 66).
C. D. E. Generalized dystonia Multifocal dystonia: affects two or more non-contiguous parts Hemidystonia: involves one arm and the ipsilateral leg Segmental dystonia: either cranial (two or more parts of cranial and neck musculature), axial (neck and trunk), brachial (arm and axial or both arms ± neck, ± trunk), or crural (one leg and trunk or both legs ± trunk) Focal dystonia: affecting a single site such as eyelids (blepharospasm), mouth (oromandibular dystonia), larynx (spastic dysphonia), neck (torticollis), or arm (writer’s cramp) 38 AN ILLUSTRATED POCKETBOOK OF PARKINSON’S DISEASE Figure 40 Olivopontocerebellar atrophy: axial T2-weighted (upper) and proton density (lower) MRIs showing areas of hyperintensity.
An Illustrated Pocketbook of Parkinson’s Disease and Related Disorders by G. David Perkin